Many people are taken by surprise when their spouse picks up My Wife Left Me and Won't Talk to Me and leaves them. I have seen it happen all too often. The worse case scenario is when your spouse leaves and refuses to talk to you. How can you begin to make amends when one person has cut off all communication? Don't stress out if your wife won't talk to you. After a sufficient amount of time, your wife will open up again and you should be ready when it happens.
When you are able to get a hold of your spouse, I wouldn't recommend starting out the conversation with blame. It's too easy to blame one another for the problems in your marriage. If you begin your conversation with an attitude of "it's your fault," you will be right back where you started. Your wife will not want to talk to you because it always ends up in fighting. Your best bet is to speak calmly and don't place blame.
Also be prepared to listen. Although your wife may not have spoken to you in some time, she still has plenty to say. Often times, not speaking at all is a strategy used to win a fight. This is because you have no idea what she is thinking about if she isn't speaking to you. You could drive yourself nuts trying to work things out and she probably knows this. Therefore, when she is ready to talk, your job is to listen. Let her get all of her concerns out in the open. Don't try to win the conversation because that will only start another argument.
Don't be afraid to bring up getting back together. Bringing up the topic will also bring up what changes need to be made for your relationship to work again. Your wife may give you a list of her changes and you can do the same. The important thing is that you both are talking and getting to the root of the problems in your marriage.